A polypeptide member of the transforming growth factor beta superfamily of cytokines

Dependent Recognition Of Cytokine responses

Dependent Recognition Of Cytokine responses

tgf-b1

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell perform

 

Pure interferon-producing cells (IPC) reply to viruses by secreting sort I interferon (IFN) and interleukin-12 (IL-12). Toll-like receptor (TLR) 9 mediates IPC recognition of a few of these viruses in vitro. Nonetheless, whether or not TLR9-induced activation of IPC is important for an efficient antiviral response in vivo is just not clear. Right here, we display that IPC and dendritic cells (DC) acknowledge murine cytomegalovirus (MCMV) via TLR9. TLR9-mediated cytokine secretion promotes viral clearance by NK cells that categorical the MCMV-specific receptor Ly49H.
Though depletion of IPC results in a drastic discount of the IFN-alpha response, this permits different cell varieties to secrete IL-12, guaranteeing regular IFN-gamma and NK cell responses to MCMV. We conclude that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and presumably different cell varieties, that are coordinated to advertise efficient NK cell perform and MCMV clearance.
tgf-b1
tgf-b1

DOCK1 Antibody, Biotin conjugated

 

Proof has collected that cytokines have a elementary position within the differentiation of reminiscence T cells. Right here, we observe the CD8+ T cell from preliminary activation to memory-cell technology, indicating the checkpoints at which cytokines decide the destiny of the T cell.

Members of the frequent cytokine-receptor gamma-chain (gammac)-cytokine family–in explicit, interleukin-7 (IL-7) and IL-15–act at every stage of the immune response to advertise proliferation and survival. On this method, a secure and protecting, long-lived reminiscence CD8+ T-cell pool might be propagated and maintained.

 

tgf-b1
tgf-b1

 

DOCK1 antibody

70R-12505 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal DOCK1 antibody

DOCK1 antibody

70R-21517 50 ul
EUR 435
Description: Rabbit polyclonal DOCK1 antibody

DOCK1 antibody

70R-35827 100 ug
EUR 327
Description: Rabbit polyclonal DOCK1 antibody

Anti-DOCK1 antibody

STJ70065 100 µg
EUR 359

Anti-DOCK1 antibody

STJ119485 100 µl
EUR 277
Description: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

DOCK1 Conjugated Antibody

C34642 100ul
EUR 397

DOCK1 siRNA

20-abx914478
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

DOCK1 siRNA

20-abx914479
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

DOCK1 Peptide

45-489P 0.1 mg
EUR 338
Description: DOCK1 Peptide

DOCK1 Antibody, HRP conjugated

1-CSB-PA619864LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK1. Recognizes DOCK1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DOCK1 Antibody, FITC conjugated

1-CSB-PA619864LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK1. Recognizes DOCK1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

DOCK1 Antibody, Biotin conjugated

1-CSB-PA619864LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK1. Recognizes DOCK1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Human DOCK1 shRNA Plasmid

20-abx951246
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

DOCK1 Rabbit pAb

A17359-100ul 100 ul
EUR 308

DOCK1 Rabbit pAb

A17359-50ul 50 ul
EUR 223

DOCK1 Rabbit pAb

A17359-200ul 200 ul
EUR 459

DOCK1 Rabbit pAb

A17359-20ul 20 ul
EUR 183

DOCK1 Blocking Peptide

DF3984-BP 1mg
EUR 195

Anti-DOCK1 (3D10)

YF-MA12721 100 ug
EUR 363
Description: Mouse monoclonal to DOCK1

Polyclonal Goat Anti-DOCK1 Antibody

AMM04959G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-DOCK1 . This antibody is tested and proven to work in the following applications:

DOCK1 ELISA Kit (Human) (OKCA01197)

OKCA01197 96 Wells
EUR 846
Description: Description of target: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sanadwich ELISA;Sensitivity: 11.7 pg/mL

DOCK1 ORF Vector (Human) (pORF)

ORF018475 1.0 ug DNA
EUR 659

Mouse DOCK1 shRNA Plasmid

20-abx983627
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Dedicator of Cytokinesis 1 (DOCK1) Antibody

20-abx112009
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Dedicator of Cytokinesis 1 (DOCK1) Antibody

20-abx102732
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dedicator of Cytokinesis 1 (DOCK1) Antibody

20-abx014419
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Dedicator of Cytokinesis 1 (DOCK1) Antibody

abx431929-200ul 200 ul
EUR 384

Dedicator of Cytokinesis 1 (DOCK1) Antibody

abx147652-100ug 100 ug
EUR 439

Dedicator Of Cytokinesis 1 (DOCK1) Antibody

20-abx211608
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Dedicator Of Cytokinesis 1 (DOCK1) Antibody

abx330938-100ul 100 ul
EUR 425

Dedicator Of Cytokinesis 1 (DOCK1) Antibody

20-abx325559
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Antibody

20-abx333995
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DOCK1 sgRNA CRISPR Lentivector set (Human)

K0623601 3 x 1.0 ug
EUR 339

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human)

4-PAG175Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1)

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (HRP)

20-abx335295
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (FITC)

20-abx335296
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (Biotin)

20-abx335297
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), APC

4-PAG175Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with APC.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), Biotinylated

4-PAG175Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with Biotin.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), Cy3

4-PAG175Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with Cy3.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), FITC

4-PAG175Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with FITC.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), HRP

4-PAG175Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with HRP.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), PE

4-PAG175Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with PE.

DOCK1 ELISA Kit (Mouse) (OKCA01654)

OKCA01654 96 Wells
EUR 846
Description: Description of target: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sanadwich ELISA;Sensitivity: 15.6 pg/mL

Dock1 ORF Vector (Rat) (pORF)

ORF066160 1.0 ug DNA
EUR 2080

Dock1 ORF Vector (Mouse) (pORF)

ORF043261 1.0 ug DNA
EUR 1572

Human Dedicator Of Cytokinesis 1 (DOCK1) Protein

20-abx066282
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

DOCK1 sgRNA CRISPR Lentivector (Human) (Target 1)

K0623602 1.0 ug DNA
EUR 154

DOCK1 sgRNA CRISPR Lentivector (Human) (Target 2)

K0623603 1.0 ug DNA
EUR 154

DOCK1 sgRNA CRISPR Lentivector (Human) (Target 3)

K0623604 1.0 ug DNA
EUR 154

DOCK1 Protein Vector (Human) (pPB-C-His)

PV073897 500 ng
EUR 2890

DOCK1 Protein Vector (Human) (pPB-N-His)

PV073898 500 ng
EUR 2890

DOCK1 Protein Vector (Human) (pPM-C-HA)

PV073899 500 ng
EUR 2890

DOCK1 Protein Vector (Human) (pPM-C-His)

PV073900 500 ng
EUR 2890

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), APC-Cy7

4-PAG175Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with APC-Cy7.

Recombinant Dedicator Of Cytokinesis 1 (DOCK1)

4-RPG175Hu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Dedicator Of Cytokinesis 1 expressed in: E.coli

Dock1 sgRNA CRISPR Lentivector set (Mouse)

K4606301 3 x 1.0 ug
EUR 339

Dock1 sgRNA CRISPR Lentivector set (Rat)

K6464301 3 x 1.0 ug
EUR 339

Human Dedicator Of Cytokinesis Protein 1 (DOCK1) ELISA Kit

abx259546-96tests 96 tests
EUR 911

Human Dedicator of cytokinesis protein 1, DOCK1 ELISA KIT

ELI-09218h 96 Tests
EUR 824

Dock1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4606302 1.0 ug DNA
EUR 154

Dock1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4606303 1.0 ug DNA
EUR 154

Dock1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4606304 1.0 ug DNA
EUR 154

Dock1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6464302 1.0 ug DNA
EUR 154

Dock1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6464303 1.0 ug DNA
EUR 154

Dock1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6464304 1.0 ug DNA
EUR 154

Dock1 3'UTR GFP Stable Cell Line

TU253569 1.0 ml Ask for price

Dock1 3'UTR Luciferase Stable Cell Line

TU203569 1.0 ml Ask for price

Dock1 3'UTR GFP Stable Cell Line

TU155315 1.0 ml Ask for price

Dock1 3'UTR Luciferase Stable Cell Line

TU105315 1.0 ml Ask for price

DOCK1 3'UTR Luciferase Stable Cell Line

TU006231 1.0 ml
EUR 1364

DOCK1 3'UTR GFP Stable Cell Line

TU056231 1.0 ml
EUR 1364

DOCK1 Protein Vector (Mouse) (pPB-C-His)

PV173042 500 ng
EUR 3093

DOCK1 Protein Vector (Mouse) (pPB-N-His)

PV173043 500 ng
EUR 3093

DOCK1 Protein Vector (Mouse) (pPM-C-HA)

PV173044 500 ng
EUR 3093

DOCK1 Protein Vector (Mouse) (pPM-C-His)

PV173045 500 ng
EUR 3093

DOCK1 Protein Vector (Rat) (pPB-C-His)

PV264638 500 ng
EUR 3092

DOCK1 Protein Vector (Rat) (pPB-N-His)

PV264639 500 ng
EUR 3092

DOCK1 Protein Vector (Rat) (pPM-C-HA)

PV264640 500 ng
EUR 3092

DOCK1 Protein Vector (Rat) (pPM-C-His)

PV264641 500 ng
EUR 3092

DOCK1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0623605 3 x 1.0 ug
EUR 376

DOCK1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV654325 1.0 ug DNA
EUR 2878

DOCK1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV654329 1.0 ug DNA
EUR 2878

DOCK1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV654330 1.0 ug DNA
EUR 2878

DOCK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0623606 1.0 ug DNA
EUR 167

DOCK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0623607 1.0 ug DNA
EUR 167

DOCK1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0623608 1.0 ug DNA
EUR 167

The position of cytokines in osteoarthritis pathophysiology.

Morphological adjustments noticed in OA embrace cartilage erosion in addition to a variable diploma of synovial irritation. Present analysis attributes these adjustments to a posh community of biochemical elements, together with proteolytic enzymes, that result in a breakdown of the cartilage macromolecules. Cytokines akin to IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself considerably up-regulate metalloproteinases (MMP) gene expression.
  1. Cytokines additionally blunt chondrocyte compensatory synthesis pathways required to revive the integrity of the degraded extrecellular matrix (ECM). Furthermore, in OA synovium, a relative deficit within the manufacturing of pure antagonists of the IL-1 receptor (IL-1Ra) has been demonstrated, and will presumably be associated to an extra manufacturing of nitric oxide in OA tissues.
  2. This, coupled with an upregulation within the receptor stage, has been proven to be a further enhancer of the catabolic impact of IL-1 on this illness.IL-1 and TNF-alpha considerably up-regulate MMP-Three steady-state mRNA derived from human synovium and chondrocytes.
  3. The neutralization of IL-1 and/or TNF-alpha up-regulation of MMP gene expression seems to be a logical improvement within the potential medical remedy of OA. Certainly, recombinant IL-1receptor antagonists (ILRa) and soluble IL-1 receptor proteins have been examined in each animal fashions of OA for modification of OA development.
  4. Soluble IL-1Ra suppressed MMP-Three transcription within the rabbit synovial cell line HIG-82. Experimental proof displaying that neutralizing TNF-alpha suppressed cartilage degradation in arthritis additionally help such technique.
  5. The vital position of TNF-alpha in OA could emerge from the truth that human articular chondrocytes from OA cartilage expressed a considerably greater variety of the p55 TNF-alpha receptor which might make OA cartilage significantly vulnerable to TNF-alpha degradative stimuli.
  6. As well as, OA cartilage produces extra TNF-alpha and TNF anglealpha convertase enzyme (TACE) mRNA than regular cartilage. By analogy, an inhibitor to the p55 TNF-alpha receptor can also present a mechanism for abolishing TNF-alpha-induced degradation of cartilage ECM by MMPs.

    Dedicator of Cytokinesis 1 (DOCK1) Antibody

  7. Since TACE is the regulator of TNF-alpha exercise, limiting the exercise of TACE may additionally show efficacious in OA. IL-1 and TNF-alpha inhibition of chondrocyte compensatory biosynthesis pathways which additional compromise cartilage restore should even be handled, maybe by using stimulatory brokers akin to remodeling development factor-beta or insulin-like development factor-I.
  8. Sure cytokines have antiinflammatory properties. Three such cytokines – IL-4, IL-10, and IL-13 – have been recognized as in a position to modulate numerous inflammatory processes. Their antiinflammatory potential, nonetheless, seems to rely vastly on the goal cell.
  9. Interleukin-4 (IL-4) has been examined in vitro in OA tissue and has been proven to suppress the synthesis of each TNF-alpha and IL-1beta in the identical method as low-dose dexamethasone. Naturally occurring antiinflammatory cytokines akin to IL-10 inhibit the synthesis of IL-1 and TNF-alpha and might be potential targets for remedy in OA.
  10. Augmenting inhibitor manufacturing in situ by gene remedy or supplementing it by injecting the recombinant protein is a beautiful therapeutic goal, though an in vivo assay in OA is just not obtainable, and its applicability has but to be confirmed.
  11. Equally, IL-13 considerably inhibits lipopolysaccharide (LPS)-induced TNF-alpha manufacturing by mononuclear cells from peripheral blood, however not in cells from infected synovial fluid. IL-13 has vital organic actions: inhibition of the manufacturing of a variety of proinflammatory cytokines in monocytes/macrophages, B cells, pure killer cells and endothelial cells, whereas growing IL-1Ra manufacturing.
  12. In OA synovial membranes handled with LPS, IL-13 inhibited the synthesis of IL-1beta, TNF-alpha and stromelysin, whereas growing IL-1Ra manufacturing.
  13. In abstract, modulation of cytokines that management MMP gene up-regulation would look like fertile targets for drug improvement within the therapy of OA. A number of research illustrate the potential significance of modulating IL-1 exercise as a way to cut back the development of the structural adjustments in OA.
  14. Within the experimental canine and rabbit fashions of OA, we’ve got demonstrated that in vivo intraarticular injections of the IL-Ra gene can forestall the development of structural adjustments in OA. Future instructions within the analysis and therapy of osteoarthritis (OA) will likely be primarily based on the rising image of pathophysiological occasions that modulate the initiation and development of OA.

PRC1 Antibody

1-CSB-PA102179
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PRC1. Recognizes PRC1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

PRC1 Antibody

1-CSB-PA018633GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against PRC1. Recognizes PRC1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

PRC1 Antibody

1-CSB-PA781917
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PRC1. Recognizes PRC1 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000

PRC1 Antibody

DF2955 200ul
EUR 304
Description: PRC1 Antibody detects endogenous levels of total PRC1.

PRC1 Antibody

ABD2955 100 ug
EUR 438

pENTR223-PRC1

PVT12260 2 ug
EUR 703

PRC1 antibody

70R-19498 50 ul
EUR 435
Description: Rabbit polyclonal PRC1 antibody

PRC1 Peptide

6821P 0.05 mg
EUR 164.75
Description: (IN) PRC1 peptide

PRC1 Antibody

6821-002mg 0.02 mg
EUR 171.82
Description: PRC1 Antibody: PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.

PRC1 Antibody

6821-01mg 0.1 mg
EUR 436.42
Description: PRC1 Antibody: PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.

HEK-293T Telomerase Over-Expressing Cell Pellet

abx069991-1Pellet 1 Pellet
EUR 398

PRC1 Polyclonal Antibody

ES8618-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PRC1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

PRC1 Polyclonal Antibody

ES8618-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PRC1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-PRC1 Antibody

PB9814 100ug/vial
EUR 294

PRC1 Polyclonal Antibody

ABP59992-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PRC1 from Human. This PRC1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PRC1 protein at amino acid sequence of 460-520

PRC1 Polyclonal Antibody

ABP59992-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PRC1 from Human. This PRC1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PRC1 protein at amino acid sequence of 460-520

PRC1 Polyclonal Antibody

ABP59992-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PRC1 from Human. This PRC1 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PRC1 protein at amino acid sequence of 460-520

PRC1 (pT470) Antibody

abx217918-100ug 100 ug
EUR 439

PRC1 (pT481) Antibody

abx217919-100ug 100 ug
EUR 439

Anti-PRC1 antibody

STJ29109 100 µl
EUR 277
Description: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.

Anti-PRC1 antibody

STJ98681 200 µl
EUR 197
Description: Rabbit polyclonal to PRC1.

Polyclonal PRC1 Antibody

APR06757G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PRC1 . This antibody is tested and proven to work in the following applications:

PRC1 Rabbit pAb

A7029-100ul 100 ul
EUR 308

PRC1 Rabbit pAb

A7029-200ul 200 ul
EUR 459

PRC1 Rabbit pAb

A7029-20ul 20 ul
EUR 183

PRC1 Rabbit pAb

A7029-50ul 50 ul
EUR 223

PRC1 cloning plasmid

CSB-CL018633HU1-10ug 10ug
EUR 233
Description: A cloning plasmid for the PRC1 gene.

PRC1 cloning plasmid

CSB-CL018633HU2-10ug 10ug
EUR 376
Description: A cloning plasmid for the PRC1 gene.

anti- PRC1 antibody

FNab06748 100µg
EUR 505.25
Description: Antibody raised against PRC1

anti- PRC1 antibody

FNab06749 100µg
EUR 585
Description: Antibody raised against PRC1

PRC1 Conjugated Antibody

C36701 100ul
EUR 397

PRC1 Blocking Peptide

DF2955-BP 1mg
EUR 195

Anti-PRC1 antibody

PAab06748 100 ug
EUR 355

Anti-PRC1 antibody

PAab06749 100 ug
EUR 412

Bradford reagent

BDE641 100ml
EUR 61.01

Beaucage reagent

HY-100951 10mM/1mL
EUR 126

BOP reagent

5-02141 25g Ask for price

BOP reagent

5-02142 100g Ask for price

Bluing Reagent

BRT030 30 ml
EUR 60

Bluing Reagent

BRT125 125 ml
EUR 63

Bluing Reagent

BRT3800 1 Gal.
EUR 184

Bluing Reagent

BRT500 500 ml
EUR 76

Bluing Reagent

BRT999 1000 ml
EUR 88

BOP reagent

A7015-100000 100 g
EUR 200
Description: A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.

BOP reagent

A7015-25000 25 g
EUR 113
Description: A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.

Traut's Reagent

2330-1000
EUR 349

Traut's Reagent

2330-500
EUR 207

MTS Reagent

2808-1000
EUR 990

MTS Reagent

2808-250
EUR 365

MTT Reagent

2809-1G
EUR 180

MTT Reagent

2809-5G
EUR 544

Chymase reagent

30C-CP1129 5 units
EUR 2185
Description: Purified native Human Chymase reagent

Mouse PRC1 shRNA Plasmid

20-abx982052
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human PRC1 shRNA Plasmid

20-abx955976
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Polyclonal PRC1 Antibody (Internal)

APR03046G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PRC1 (Internal). This antibody is tested and proven to work in the following applications:

PRC1 (Phospho-Thr470) Antibody

12694-100ul 100ul
EUR 252

PRC1 (Phospho-Thr470) Antibody

12694-50ul 50ul
EUR 187

Phospho-PRC1 (Thr481) Antibody

1-CSB-PA399087
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-PRC1 (Thr481). Recognizes Phospho-PRC1 (Thr481) from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000

Phospho-PRC1 (Thr470) Antibody

AF8393 200ul
EUR 376
Description: PRC1 (Phospho-Thr470) Antibody detects endogenous levels of PRC1 only when phosphorylated at Thr470.

Phospho-PRC1 (Thr481) Antibody

AF8394 200ul
EUR 376
Description: PRC1 (Phospho-Thr481) Antibody detects endogenous levels of PRC1 only when phosphorylated at Thr481.

PRC1 ELISA KIT|Human

EF002034 96 Tests
EUR 689

PRC1 (Phospho- Thr470) Antibody

ABF8393 100 ug
EUR 438

PRC1 (Phospho- Thr481) Antibody

ABF8394 100 ug
EUR 438

PRC1 Recombinant Protein (Mouse)

RP164219 100 ug Ask for price

Anti-PRC1 (3E3-1G1)

YF-MA16634 100 ug
EUR 363
Description: Mouse monoclonal to PRC1

Anti-PRC1 (3B10-1F9)

YF-MA16635 100 ug
EUR 363
Description: Mouse monoclonal to PRC1

PRC1 Recombinant Protein (Human)

RP024493 100 ug Ask for price

PRC1 Recombinant Protein (Human)

RP024496 100 ug Ask for price

pCS2- Myc- Prc1- m

PVT10437 2 ug
EUR 370

PRC1 Recombinant Protein (Rat)

RP221930 100 ug Ask for price

LP4K Transfection Reagent

LP4K 1.0 ml / vial
EUR 304
Description: Lipid based transfection reagent for large plasmid and multiple plasmid transfection in both adhesive and suspenstion cell types.

Tri-RNA Reagent

FATRR-001 100ml
EUR 236

Tri-RNA Reagent

FATRR-002 50ml
EUR 176

Tri-RNA Reagent

FATRR-003 450ml
EUR 645

DTT (Cleland's reagent)

DB0058 5g
EUR 84.8

DTNB (Ellman's Reagent)

DB0113 5g
EUR 97.85

n-Heptane Reagent

HC5400 1L
EUR 79

PhosphoBlocker Blocking Reagent

AKR-104 4L
EUR 711
Description: Most commercially available Western blot blockers, such as dry milk or serum, are sufficient to block unreactive sites on the membrane. However, they are not designed to preserve phosphoprotein antigens during blotting. Our PhosphoBLOCKER Blocking Reagent provides superior blocking by maximizing signal-to-noise ratio. The PhosphoBLOCKER reagent particluarly excels with very low levels of endogenous phopsphoproteins.

PhosphoBlocker Blocking Reagent

AKR-103 1L
EUR 328
Description: Most commercially available Western blot blockers, such as dry milk or serum, are sufficient to block unreactive sites on the membrane. However, they are not designed to preserve phosphoprotein antigens during blotting. Our PhosphoBLOCKER Blocking Reagent provides superior blocking by maximizing signal-to-noise ratio. The PhosphoBLOCKER reagent particluarly excels with very low levels of endogenous phopsphoproteins.

Ethyl acetate Reagent

EC4600 1L
EUR 79

EL Transfection Reagent

20-abx098880
  • EUR 384.00
  • EUR 537.00
  • 0.75 ml
  • 1.5 ml

Mycoplasma Prevention Reagent

20-abx098886
  • EUR 425.00
  • EUR 509.00
  • 1 ml
  • 5 ml

Convoy? Transfection Reagent

1110-1ml
EUR 341

FcR blocking Reagent

20-abx290024
  • EUR 377.00
  • EUR 516.00
  • 200 tests
  • 400 tests

Detection Reagent A

abx296004-120ul 120 ul
EUR 321

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