A polypeptide member of the transforming growth factor beta superfamily of cytokines

cell migration and invasion of cytokinesis 

cell migration and invasion of cytokinesis 

tgf-b1

Cortactin promotes cell migration and invasion via upregulation of the dedicator of cytokinesis 1 expression in human colorectal most cancers.

 

Cortactin (CTTN), a significant substrate of the Src tyrosine kinase, has been implicated in cell proliferation, motility and invasion in numerous forms of most cancers. Nevertheless, the molecular mechanisms of CTTN-driven malignant conduct stay unclear.

Within the present research, we decided the expression of CTTN in colorectal most cancers and investigated its underlying mechanism within the metastasis of colorectal most cancers.

We confirmed elevated CTTN expression in lymph node-positive CRC specimens and extremely invasive CRC cell strains. Additional research has proven that overexpression of CTTN promoted CRC cell migration and invasion, whereas CTTN silencing inhibited CRC cell migratory and invasive capacities in vitro.

Mechanistically, CTTN will increase expression of dedicator of cytokinesis 1 (DOCK1) and gene silencing of DOCK1 partially abolishes the migration and invasion capability by CTTN.

Our findings point out that CTTN promotes metastasis of CRC cells by rising DOCK1 expression and this might provide a promising therapeutic goal for colorectal most cancers therapy.

 

 

SMAD1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

  • Ovarian follicular cysts are one of the crucial widespread causes of reproductive failure in mammals. A comparative gene expression strategy could help in elucidating the causes of ovarian cyst illness.
  • Within the current research, the differential show approach was used to determine mRNA sequences that accumulate preferentially in theca cells of bovine cystic follicles. Dedicator of cytokinesis 6 (Dock6) expression was noticed within the theca cells of cystic follicles.
  • Small interfering RNA (siRNA) knockdown of Dock6 elevated progesterone (P4) manufacturing and StAR expression in theca cells of high-estrogen follicular cysts, however didn’t have an effect on androstenedione (A4) manufacturing.

    tgf-b1
    tgf-b1
  • We suggest that Dock6 could also be a marker related to the event of follicular cysts. Moreover, Dock6 could also be concerned within the improvement of cystic follicles by suppressing P4 manufacturing fairly than rising A4 manufacturing in theca cells.

Alpha-bungarotoxin, CF640r

9-00004
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin

00010-1 1MG
EUR 168
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin

00011 500uG
EUR 367
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin

00012 500uG
EUR 383
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)

00013 10ST
EUR 417
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)

00014 10ST
EUR 466
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)

00015 500uG
EUR 466
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)

00016 10ST
EUR 523
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin

00017 500uG
EUR 433
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:

00020 1MG
EUR 314
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)

00020-1 20ST
EUR 418
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:

00021 1MG
EUR 344
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)

00021-1 20ST
EUR 448
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:

00022 1MG
EUR 491
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)

00022-1 20ST
EUR 625
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:

00023 1MG
EUR 281
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine

00025 100uG
EUR 139
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543

00026 500uG
EUR 494
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u

00027 300
EUR 345
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin

00028 100U
EUR 428
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin

00030 300U
EUR 345
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin

00032 300ST
EUR 345
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin

00033 300EU
EUR 345
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M

00034 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M

00034-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP

00036 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP

00037 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555

00040 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647

00041 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647

00041-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A

00042 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A

00042-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543

00043 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543

00043-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568

00044 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568

00044-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594

00045 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594

00045-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633

00046 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633

00046-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

TBCE Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

BACKGROUND

Vascular easy muscle cell (SMC) phenotypic modulation and vascular reworking contribute to the event of a number of vascular issues equivalent to restenosis after angioplasty, transplant vasculopathy, and atherosclerosis. The mechanisms underlying these processes, nonetheless, stay largely unknown.

OBJECTIVE
The target of this research is to find out the function of dedicator of cytokinesis 2 (DOCK2) in SMC phenotypic modulation and vascular reworking.

RESULTS
Platelet-derived progress factor-BB induced DOCK2 expression whereas modulating SMC phenotype. DOCK2 deficiency diminishes platelet-derived progress factor-BB or serum-induced downregulation of SMC markers. Conversely, DOCK2 overexpression inhibits SMC marker expression in major cultured SMC.

Mechanistically, DOCK2 inhibits myocardin expression, blocks serum response issue nuclear location, attenuates myocardin binding to serum response issue, and thus attenuates myocardin-induced easy muscle marker promoter exercise.

Furthermore, DOCK2 and Kruppel-like issue four cooperatively inhibit myocardin-serum response issue interplay. In a rat carotid artery balloon-injury mannequin, DOCK2 is induced in media layer SMC initially and neointima SMC subsequently after vascular harm.

The knockdown of DOCK2 dramatically inhibits the neointima formation by 60%. Most significantly, knockout of DOCK2 in mice markedly blocks ligation-induced intimal hyperplasia whereas restoring SMC contractile protein expression.

CONCLUSIONS
Our research recognized DOCK2 as a novel regulator for SMC phenotypic modulation and vascular lesion formation after vascular harm. Due to this fact, focusing on DOCK2 could also be a possible therapeutic technique for the prevention of vascular reworking in proliferative vascular ailments.

 

STAT5A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

Description:
A polyclonal antibody towards Phospho-PRC1 (Thr481). Acknowledges Phospho-PRC1 (Thr481) from Human. This antibody is Unconjugated. Examined within the following utility: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000

 

EF1a Control lentiviral particles (Puro)

EF1a-Null-Puro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter.

EF1a Control lentiviral particles (GFP-Bsd)

EF1a-Null-GB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter.

EF1a Control lentiviral particles (GFP-Puro)

EF1a-Null-GP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter.

EF1a Control lentiviral particles (RFP-Bsd)

EF1a-Null-RB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter.

EF1a Control lentiviral particles (RFP-Puro)

EF1a-Null-RP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter.

EF1a control lentivirus (Hygro)

EF1a-Null-Hygro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

EF1a control lentivirus (Zeo)

EF1a-Null-Zeo 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

EF1a Control lentiviral particles (Bsd) in PBS

EF1a-Null-Bsd-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the blasticidin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (Neo) in PBS

EF1a-Null-Neo-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Neomycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (Puro) in PBS

EF1a-Null-Puro-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (GFP-Bsd) in PBS

EF1a-Null-GB-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (GFP-Puro) in PBS

EF1a-Null-GP-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (RFP-Bsd) in PBS

EF1a-Null-RB-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EF1a Control lentiviral particles (RFP-Puro) in PBS

EF1a-Null-RP-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

HPC1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728674 1.0 ug DNA Ask for price

HPCX Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728680 1.0 ug DNA Ask for price

HPE1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728686 1.0 ug DNA Ask for price

HPFH2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728692 1.0 ug DNA Ask for price

HPLH1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728698 1.0 ug DNA Ask for price

HPP1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728704 1.0 ug DNA Ask for price

HPRTP2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728710 1.0 ug DNA Ask for price

HPRTP3 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728716 1.0 ug DNA Ask for price

HPRTP4 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728722 1.0 ug DNA Ask for price

HPT Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728728 1.0 ug DNA Ask for price

HPV6AI1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728734 1.0 ug DNA Ask for price

HPV18I1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728740 1.0 ug DNA Ask for price

HPV18I2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728746 1.0 ug DNA Ask for price

HRES1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728752 1.0 ug DNA Ask for price

HRPT1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728758 1.0 ug DNA Ask for price

HSBP1P1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728776 1.0 ug DNA Ask for price

HSD3BP1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728782 1.0 ug DNA Ask for price

HSD3BP2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728788 1.0 ug DNA Ask for price

HSD3BP3 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728794 1.0 ug DNA Ask for price

HSD3BP4 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728800 1.0 ug DNA Ask for price

HSD3BP5 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728806 1.0 ug DNA Ask for price

HSFX2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728812 1.0 ug DNA Ask for price

HSFY4P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728818 1.0 ug DNA Ask for price

HSFY5P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728824 1.0 ug DNA Ask for price

HSFY6P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728830 1.0 ug DNA Ask for price

HSFY7P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728836 1.0 ug DNA Ask for price

HSFY8P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV728842 1.0 ug DNA Ask for price

 

 


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