A polypeptide member of the transforming growth factor beta superfamily of cytokines

 Cytokines and Myeloid Induces human bronchial fibroblasts

 Cytokines and Myeloid Induces human bronchial fibroblasts

tgf-b1

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

 

The polarization of adipose tissue-resident macrophages towards the alternatively activated, anti-inflammatory M2 phenotype is believed to enhance insulin sensitivity. Nevertheless, the mechanisms controlling tissue macrophage activation stay unclear.
Right here we present that adipocytes are a supply of Th2 cytokines, together with IL-13 and to a lesser extent IL-4, which induce macrophage PPARdelta/beta (Ppard/b) expression by a STAT6 binding website on its promoter to activate various activation. Coculture research point out that Ppard ablation renders macrophages incapable of transition to the M2 phenotype, which in turns causes irritation and metabolic derangement in adipocytes.
tgf-b1
tgf-b1
Remarkably, an analogous regulatory mechanism by hepatocyte-derived Th2 cytokines and macrophage PPARdelta is discovered to regulate hepatic lipid metabolism. The physiological relevance of this paracrine pathway is demonstrated in myeloid-specific PPARdelta(-/-) mice, which develop insulin resistance and present elevated adipocyte lipolysis and extreme hepatosteatosis. These findings present a molecular foundation to modulate tissue-resident macrophage activation and insulin sensitivity.

 

IL-17 is elevated in asthmatic airways and induces human bronchial fibroblasts to supply cytokines.

 

 

BACKGROUND
IL-17 is a cytokine that has been reported to be produced by T lymphocytes. In vitro, IL-17 prompts fibro-blasts and macrophages for the secretion of GM-CSF, TNF-alpha, IL-1beta, and IL-6. Quite a few these cytokines are concerned within the airway reworking that’s noticed inside the lungs of asthmatic people.
OBJECTIVE
On this examine, we investigated the expression of IL-17 in sputum and bronchoalveolar lavage specimens obtained from asthmatic topics and from nonasthmatic management topics.
METHODS
IL-17 was detected by use of immunocytochemistry, in situ hybridization, and Western blot. Bronchial fibroblasts have been stimulated with IL-17, and cytokine manufacturing and chemokine manufacturing have been detected by use of ELISA and RT-PCR.
RESULTS
Utilizing immunocytochemistry, we demonstrated that the numbers of cells optimistic for IL-17 are considerably elevated in sputum and bronchoalveolar lavage fluids of topics with bronchial asthma compared with management topics (P <.001 and P <.005, respectively).
We demonstrated that along with T cells, eosinophils in sputum and bronchoalveolar lavage fluids expressed IL-17. Peripheral blood eosinophils have been additionally optimistic for IL-17, and the extent of IL-17 in eosinophils purified from peripheral blood was considerably greater in topics with bronchial asthma than in controls (P <.01).
To additional examine the mechanism of motion of IL-17 in vivo, we examined the impact of this cytokine on fibroblasts remoted from bronchial biopsies of asthmatic and nonasthmatic topics. IL-17 did improve the manufacturing of pro-fibrotic cytokines (IL-6 and IL-11) by fibroblasts, and this was inhibited by dexamethasone.
Equally, IL-17 elevated the extent of different fibroblast-derived inflammatory mediators, such because the alpha-chemokines, IL-8, and growth-related oncogene-alpha.
CONCLUSIONS
Our outcomes, which show for the primary time that eosinophils are a possible supply of IL-17 inside asthmatic airways, recommend that IL-17 may need the potential to amplify inflammatory responses by the discharge of proinflammatory mediators corresponding to alpha-chemokines.

 

 

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human)

4-PAG175Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1)

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (HRP)

20-abx335295
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (FITC)

20-abx335296
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Antibody (Biotin)

20-abx335297
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Dedicator Of Cytokinesis 1 (DOCK1) Protein

20-abx066282
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), APC

4-PAG175Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with APC.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), Biotinylated

4-PAG175Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with Biotin.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), Cy3

4-PAG175Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with Cy3.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), FITC

4-PAG175Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with FITC.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), HRP

4-PAG175Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with HRP.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), PE

4-PAG175Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with PE.

Dedicator Of Cytokinesis 1 (DOCK1) Polyclonal Antibody (Human), APC-Cy7

4-PAG175Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 1 (DOCK1). This antibody is labeled with APC-Cy7.

Human Dedicator Of Cytokinesis Protein 1 (DOCK1) ELISA Kit

abx259546-96tests 96 tests
EUR 911

Mouse Dedicator of cytokinesis protein 1, Dock1 ELISA KIT

ELI-47076m 96 Tests
EUR 865

Human Dedicator of cytokinesis protein 1, DOCK1 ELISA KIT

ELI-09218h 96 Tests
EUR 824

Dedicator of Cytokinesis 2 (DOCK2) Antibody

20-abx126888
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

Dedicator of Cytokinesis 2 (DOCK2) Antibody

20-abx129016
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dedicator of Cytokinesis 4 (DOCK4) Antibody

20-abx129252
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Dedicator of Cytokinesis 2 (DOCK2) Antibody

20-abx112010
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Dedicator of Cytokinesis 3 (DOCK3) Antibody

20-abx112011
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Dedicator of Cytokinesis 3 (DOCK3) Antibody

20-abx313603
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis 2 (DOCK2) Antibody

20-abx149900
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Dedicator Of Cytokinesis 3 (DOCK3) Antibody

20-abx176110
  • EUR 1205.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Dedicator Of Cytokinesis 3 (DOCK3) Antibody

20-abx172052
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Dedicator Of Cytokinesis 4 (DOCK4) Antibody

20-abx172053
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Dedicator Of Cytokinesis 2 (DOCK2) Antibody

20-abx326569
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human)

4-PAG182Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2)

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human)

4-PAG184Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4)

Recombinant Dedicator Of Cytokinesis 2 (DOCK2)

4-RPG182Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Dedicator Of Cytokinesis 2 expressed in: E.coli

Recombinant Dedicator Of Cytokinesis 4 (DOCK4)

4-RPG184Hu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Dedicator Of Cytokinesis 4 expressed in: E.coli

Dedicator of Cytokinesis Protein 5 (DOCK5) Antibody

abx122686-100ug 100 ug
EUR 391

Dedicator of Cytokinesis Protein 5 (DOCK5) Antibody

20-abx311377
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis 3 (DOCK3) Antibody (HRP)

20-abx313604
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis 3 (DOCK3) Antibody (FITC)

20-abx313605
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis 3 (DOCK3) Antibody (Biotin)

20-abx313606
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis Protein 10 (DOCK10) Antibody

abx145342-100ug 100 ug
EUR 391

Dedicator of Cytokinesis Protein 11 (DOCK11) Antibody

20-abx007957
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Dedicator of Cytokinesis Protein 10 (DOCK10) Antibody

20-abx301562
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dedicator of Cytokinesis Protein 11 (DOCK11) Antibody

20-abx219454
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), APC

4-PAG182Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with APC.

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), Biotinylated

4-PAG182Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with Biotin.

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), Cy3

4-PAG182Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with Cy3.

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), FITC

4-PAG182Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with FITC.

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), HRP

4-PAG182Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with HRP.

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), PE

4-PAG182Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with PE.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), APC

4-PAG184Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with APC.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), Biotinylated

4-PAG184Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with Biotin.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), Cy3

4-PAG184Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with Cy3.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), FITC

4-PAG184Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with FITC.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), HRP

4-PAG184Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with HRP.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), PE

4-PAG184Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with PE.

Mouse Dedicator of cytokinesis protein 8 (Dock8)

1-CSB-YP807451MO1
  • EUR 586.00
  • EUR 299.00
  • EUR 2172.00
  • EUR 900.00
  • EUR 1442.00
  • EUR 382.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Dedicator of cytokinesis protein 8(Dock8),partial expressed in Yeast

Human Dedicator of cytokinesis protein 8 (DOCK8)

1-CSB-YP836734HU
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Dedicator of cytokinesis protein 8(DOCK8),partial expressed in Yeast

Human Dedicator of cytokinesis protein 8 (DOCK8)

1-CSB-YP836734HUb0
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Dedicator of cytokinesis protein 8(DOCK8),partial expressed in Yeast

Mouse Dedicator of cytokinesis protein 8 (Dock8)

1-CSB-EP807451MO
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Dedicator of cytokinesis protein 8(Dock8),partial expressed in E.coli

Mouse Dedicator of cytokinesis protein 8 (Dock8)

1-CSB-EP807451MO1
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Dedicator of cytokinesis protein 8(Dock8),partial expressed in E.coli

Human Dedicator Of Cytokinesis 3 (DOCK3) Protein

20-abx653130
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Dedicator Of Cytokinesis 2 (DOCK2) Protein

20-abx166509
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Dedicator Of Cytokinesis 4 (DOCK4) Protein

20-abx168105
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant mouse Dedicator of cytokinesis protein 8

P2375 100ug Ask for price
Description: Recombinant protein for mouse Dedicator of cytokinesis protein 8

Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody (Human), APC-Cy7

4-PAG182Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 2 (DOCK2). This antibody is labeled with APC-Cy7.

Dedicator Of Cytokinesis 4 (DOCK4) Polyclonal Antibody (Human), APC-Cy7

4-PAG184Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Dedicator Of Cytokinesis 4 (DOCK4). This antibody is labeled with APC-Cy7.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

SEG183Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

SEG183Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

SEG183Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

SEG183Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

4-SEG183Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

SEG184Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

SEG184Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

SEG184Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

SEG184Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in Tissue homogenates and other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

4-SEG184Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

RD-DOCK3-Hu-48Tests 48 Tests
EUR 521

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

RD-DOCK3-Hu-96Tests 96 Tests
EUR 723

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

RD-DOCK4-Hu-48Tests 48 Tests
EUR 521

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

RD-DOCK4-Hu-96Tests 96 Tests
EUR 723

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

DLR-DOCK3-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in samples from tissue homogenates or other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

DLR-DOCK3-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Dedicator Of Cytokinesis 3 (DOCK3) in samples from tissue homogenates or other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

DLR-DOCK4-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in samples from tissue homogenates or other biological fluids.

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

DLR-DOCK4-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Dedicator Of Cytokinesis 4 (DOCK4) in samples from tissue homogenates or other biological fluids.

Human Dedicator Of Cytokinesis 3 (DOCK3) CLIA Kit

20-abx495120
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Dedicator Of Cytokinesis 4 (DOCK4) CLIA Kit

20-abx495121
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

20-abx151335
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

20-abx151336
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

RDR-DOCK3-Hu-48Tests 48 Tests
EUR 544

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit

RDR-DOCK3-Hu-96Tests 96 Tests
EUR 756

Human Dedicator Of Cytokinesis 4 (DOCK4) ELISA Kit

RDR-DOCK4-Hu-48Tests 48 Tests
EUR 544

Cytokine-secreting follicular T cells form the antibody repertoire

 

Excessive-affinity antibodies are important for host safety and underlie profitable vaccines. The technology of such antibodies requires T cell-dependent assist, which mediates germinal middle reactions through which mutation and choice of B cells happens.
Utilizing an interleukin 4-reporter system, we present right here that CD4(+) follicular helper T cells constituted primarily all the cytokine-secreting T cells in lymph nodes and have been functionally distinct from T cells secreting the identical cytokine in peripheral tissues.
Follicular helper T cells with totally different cytokine profiles might be remoted as conjugates with B cells present process cytokine-specific immunoglobulin class switching with proof of somatic hypermutation. Our findings assist a mannequin through which B cells compete for cytokines produced by follicular helper T cells that form the affinity and isotype of the antibody response.

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine manufacturing.

 

Programmed death-1 ligand (PD-L)1 and PD-L2 are ligands for programmed death-1 (PD-1), a member of the CD28/CTLA4 household expressed on activated lymphoid cells. PD-1 incorporates an immunoreceptor tyrosine-based inhibitory motif and mice poor in PD-1 develop autoimmune issues suggesting a defect in peripheral tolerance.
Human PD-L1 and PD-L2 are expressed on immature dendritic cells (iDC) and mature dendritic cells (mDC), IFN-gamma-treated monocytes, and follicular dendritic cells. Utilizing mAbs, we present that blockade of PD-L2 on dendritic cells leads to enhanced T cell proliferation and cytokine manufacturing, together with that of IFN-gamma and IL-10, whereas blockade of PD-L1 leads to comparable, extra modest, results. Blockade of each PD-L1 and PD-L2 confirmed an additive impact.
Each complete mAb and Fab enhanced T cell activation, displaying that PD-L1 and PD-L2 operate to inhibit T cell activation. Enhancement of T cell activation was most pronounced with weak APC, corresponding to iDCs and IL-10-pretreated mDCs, and fewer pronounced with robust APC corresponding to mDCs.
These knowledge are in step with the speculation that iDC have a stability of stimulatory vs inhibitory molecules that favors inhibition, and point out that PD-L1 and PD-L2 contribute to the poor stimulatory capability of iDC. PD-L1 expression differs from PD-L2 in that PD-L1 is expressed on activated T cells, placental trophoblasts, myocardial endothelium, and cortical thymic epithelial cells.
In distinction, PD-L2 is expressed on placental endothelium and medullary thymic epithelial cells. PD-L1 can also be extremely expressed on most carcinomas however minimally expressed on adjoining regular tissue suggesting a task in attenuating antitumor immune responses.

DOCK7 Polyclonal Antibody

ABP58407-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of DOCK7 from Human, Mouse. This DOCK7 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human DOCK7 protein

DOCK7 Antibody

1-CSB-PA007103GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against DOCK7. Recognizes DOCK7 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

DOCK7 Antibody

1-CSB-PA836266LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK7. Recognizes DOCK7 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:5000, IF:1:50-1:200

DOCK7 Antibody

45916-100ul 100ul
EUR 252

DOCK7 Antibody

45916-50ul 50ul
EUR 187

DOCK7 Antibody

DF9433 200ul
EUR 304
Description: DOCK7 Antibody detects endogenous levels of total DOCK7.

DOCK7 Antibody

ABD9433 100 ug
EUR 438

DOCK7 antibody

10R-1709 50 ug
EUR 242
Description: Mouse monoclonal DOCK7 antibody

DOCK7 antibody

70R-16908 50 ul
EUR 435
Description: Rabbit polyclonal DOCK7 antibody

Anti-DOCK7 antibody

STJ190740 200 µl
EUR 197
Description: Unconjugated Rabbit polyclonal to DOCK7

anti- DOCK7 antibody

FNab02497 100µg
EUR 505.25
Description: Antibody raised against DOCK7

DOCK7 Conjugated Antibody

C45916 100ul
EUR 397

Anti-DOCK7 antibody

STJ119407 100 µl
EUR 277

Anti-DOCK7 antibody

PAab02497 100 ug
EUR 355

DOCK7 siRNA

20-abx914489
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

anti-DOCK7

YF-PA21581 50 ul
EUR 363
Description: Mouse polyclonal to DOCK7

anti-DOCK7

YF-PA21582 50 ug
EUR 363
Description: Mouse polyclonal to DOCK7

DOCK7 Antibody, HRP conjugated

1-CSB-PA836266LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK7. Recognizes DOCK7 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DOCK7 Antibody, FITC conjugated

1-CSB-PA836266LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK7. Recognizes DOCK7 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

DOCK7 Antibody, Biotin conjugated

1-CSB-PA836266LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against DOCK7. Recognizes DOCK7 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

DOCK7 Rabbit pAb

A17236-100ul 100 ul
EUR 308

DOCK7 Rabbit pAb

A17236-200ul 200 ul
EUR 459

DOCK7 Rabbit pAb

A17236-20ul 20 ul
EUR 183

DOCK7 Rabbit pAb

A17236-50ul 50 ul
EUR 223

DOCK7 Blocking Peptide

DF9433-BP 1mg
EUR 195

Docking Protein 7 (DOCK7) Antibody

20-abx302482
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Docking Protein 7 (DOCK7) Antibody

20-abx149901
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Docking Protein 7 (DOCK7) Antibody

20-abx112012
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Docking Protein 7 (DOCK7) Antibody

abx232497-100ug 100 ug
EUR 481

Human DOCK7 shRNA Plasmid

20-abx963808
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

DOCK7 ELISA KIT|Human

EF009195 96 Tests
EUR 689

Docking Protein 7 (DOCK7) Antibody (HRP)

20-abx314581
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Docking Protein 7 (DOCK7) Antibody (FITC)

20-abx314582
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Docking Protein 7 (DOCK7) Antibody (Biotin)

20-abx314583
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dock7 ORF Vector (Rat) (pORF)

ORF066163 1.0 ug DNA
EUR 2308

Dock7 ORF Vector (Mouse) (pORF)

ORF043269 1.0 ug DNA
EUR 2287

DOCK7 ORF Vector (Human) (pORF)

ORF018480 1.0 ug DNA
EUR 405

DOCK7 sgRNA CRISPR Lentivector set (Human)

K0624201 3 x 1.0 ug
EUR 339

Dock7 sgRNA CRISPR Lentivector set (Rat)

K7384101 3 x 1.0 ug
EUR 339

Dock7 sgRNA CRISPR Lentivector set (Mouse)

K4401001 3 x 1.0 ug
EUR 339

DOCK7 sgRNA CRISPR Lentivector (Human) (Target 1)

K0624202 1.0 ug DNA
EUR 154

DOCK7 sgRNA CRISPR Lentivector (Human) (Target 2)

K0624203 1.0 ug DNA
EUR 154

DOCK7 sgRNA CRISPR Lentivector (Human) (Target 3)

K0624204 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Rat) (Target 1)

K7384102 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Rat) (Target 2)

K7384103 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7384104 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4401003 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4401002 1.0 ug DNA
EUR 154

Dock7 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4401004 1.0 ug DNA
EUR 154

Dock7 3'UTR GFP Stable Cell Line

TU253573 1.0 ml Ask for price

Dock7 3'UTR Luciferase Stable Cell Line

TU203573 1.0 ml Ask for price

Dock7 3'UTR GFP Stable Cell Line

TU155323 1.0 ml Ask for price

Dock7 3'UTR Luciferase Stable Cell Line

TU105323 1.0 ml Ask for price

DOCK7 3'UTR Luciferase Stable Cell Line

TU006237 1.0 ml
EUR 1394

DOCK7 3'UTR GFP Stable Cell Line

TU056237 1.0 ml
EUR 1394

DOCK7 Protein Vector (Mouse) (pPB-C-His)

PV173074 500 ng
EUR 3448

DOCK7 Protein Vector (Mouse) (pPB-N-His)

PV173075 500 ng
EUR 3448

DOCK7 Protein Vector (Mouse) (pPM-C-HA)

PV173076 500 ng
EUR 3448

DOCK7 Protein Vector (Mouse) (pPM-C-His)

PV173077 500 ng
EUR 3448

DOCK7 Protein Vector (Human) (pPB-C-His)

PV073917 500 ng
EUR 811

DOCK7 Protein Vector (Human) (pPB-N-His)

PV073918 500 ng
EUR 811

DOCK7 Protein Vector (Human) (pPM-C-HA)

PV073919 500 ng
EUR 811

DOCK7 Protein Vector (Human) (pPM-C-His)

PV073920 500 ng
EUR 811

DOCK7 Protein Vector (Rat) (pPB-C-His)

PV264650 500 ng
EUR 3479

DOCK7 Protein Vector (Rat) (pPB-N-His)

PV264651 500 ng
EUR 3479

DOCK7 Protein Vector (Rat) (pPM-C-HA)

PV264652 500 ng
EUR 3479

DOCK7 Protein Vector (Rat) (pPM-C-His)

PV264653 500 ng
EUR 3479

DOCK7 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV670171 1.0 ug DNA
EUR 3231

DOCK7 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV670175 1.0 ug DNA
EUR 3231

DOCK7 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV670176 1.0 ug DNA
EUR 3231

Human Dedicator Of Cytokinesis Protein 7 (DOCK7) ELISA Kit

abx386964-96tests 96 tests
EUR 911

Human Dedicator of cytokinesis protein 7, DOCK7 ELISA KIT

ELI-31733h 96 Tests
EUR 824

Mouse Dedicator of cytokinesis protein 7, Dock7 ELISA KIT

ELI-32144m 96 Tests
EUR 865

DOCK7 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0624205 3 x 1.0 ug
EUR 376

Dock7 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7384105 3 x 1.0 ug
EUR 376

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